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电子邮件: yichangjia@mail.tsinghua.edu.cn
实验室网站: http://jialab.info
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科研方向

神经功能研究是当今生命科学研究的重大问题之一,它对于我们理解脑高级认知功能,神经系统疾病发生发展,以及人工智能开发均具有重大意义。神经退行性疾病是指大脑和脊髓神经细胞丧失的一大类疾病,全世界范围数以千万病人患病,但临床上却缺少可靠的治疗药物和方案。研究神经科学的基本问题,对于我们认识神经行为发生及神经退行性疾病发病具有重要意义。本实验室感兴趣1)正常和病理条件下,特异的神经细胞的RNA代谢,以及RNA代谢紊乱所致神经退行性疾病,特别是运动神经元病,的发病机制;2)神经细胞内质网功能紊乱及其在神经退行性疾病中的作用;3)利用新一代基因操作手段构建神经退行性疾病的细胞和动物模型。我们综合运用神经生物学、分子细胞生物学、小鼠遗传学、高通量核酸测序和蛋白质组学等技术手段,在细胞和小鼠整体水平,研究以上问题。

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代表性科研论文

1.??Yichang Jia, John Mu, Susan Ackerman. (2012) Mutation of a U2 snRNA Gene Causes Global Disruption of Alternative Splicing and Neurodegeneration.Cell. 148, 296-308.

2.??Jian Zhou, Wanlu Du, Kechun Zhou, Yilin Tai, Hanlan Yao,?Yichang Jia, Yuqiang Ding, Yizheng Wang. (2008) Critical role of TRPC6 channels in the formation of excitatory synapses.?Nature Neuroscience. 11, 741-3.??

3.??YiqunYao, Xia Ding,?Yichang Jia, Chuanxin Huang, Yizheng Wang, and Yunhui Xu. (2008) Anti-tumor effect of b-elemene in glioblastoma cells 3 depends on p38 MAPK activation.?Cancer Lett. 264, 127-134.?

4.? ?Zenghua Wang, Bin Shen, Haolan Yao,?Yichang Jia, Jing Ren, Youji Feng and Yizheng Wang. (2007) Blockage of intermediate-conductance-Ca2+-activated K+ channels inhibits progression of human endometrial cancer.?Oncogene. 26, 5107-5114.?

5.? ??Chuanxin Huang,?Yichang Jia, Shenglian Yang, Biao Chen, Hongwei Sun, Feng Shen and Yizheng Wang. (2007) Characterization of ZNF23, a KRAB-containing protein that is downregulated in human cancers and inhibits cell cycle progression.?Exp.?Cell Res. 313, 254-263.

6.???Yichang Jia*, Jian Zhou*, Yilin Tai and Yizheng Wang. (2007) TRPC channels promote cerebellar granule neuron survival.?Nature Neuroscience?10, 559-567. * These authors contributed equally to this work. (also see News and Views,?Nature Neuroscience?10, 537-538)?

7.???Yan Li*,?Yichang Jia*, Kai Cui*, Ning Li, Zai-Yu Zheng, Yi-Zheng Wang and Xiao-Bing Yuan. (2005) Essential role of TRPC channels in the guidance of nerve growth cones by brain-derived neurotrophic factor.?Nature. 434, 894-898. * These authors contributed equally to this work. (also see News and Views,?Nature?434, 835-838)

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