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欧光朔

欧光朔

电子邮件:guangshuoou@mail.tsinghua.edu.cn

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研究方向:

我们选择线虫的Q神经前体细胞为研究对象,研究其通过不对称分裂、长距离迁移以及细胞凋亡,最终形成神经环路的分子细胞学机制。我们建立了活体显微成像方法,利用转盘激光共聚焦显微镜实时记录Q细胞的发育过程;我们发展了线虫条件性基因突变的技术,研究调控Q细胞发育的关键分子。我们关于线虫Q细胞的工作可以加深对于神经发育,不对称分裂,细胞迁移和细胞凋亡的认识。

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代表性科研论文:(*通讯作者)

Selected Publications (*Correspondence author)

1. ?Tian D, Diao M, Jiang Y, Sun L, Zhang Y, Chen Z, Huang S and Ou G*.(2015)? Anillin Regulates Neuronal Migration and Neurite Growth by Linking RhoG to the Actin Cytoskeleton. Current Biology. 2015, in press.

2. ? ?Li WJ, Yi P and Ou G*. (2015) Somatic? CRISPR/Cas9-induced? Mutations? Reveal? Roles? of? Embryonically? Essential? Dynein? Chains? in Caenorhabditis elegans Cilia. J. Cell Biol. 2015 March 16; 208 (6)

3. ? ?Shen Z, Zhang X, Chai Y, Zhu Z, Yi P, Feng G, Li W?and Ou?G.* (2014)??Conditional Knockouts Generated by Engineered CRISPR-Cas9 Endonuclease Reveal the Roles of Coronin in C. elegans Neural Development.?Developmental Cell. 2014 Sept? 08;30(5):625-36.

4.????Cheng Z, Yi P, Wang X, Chai Y, Feng G, Yang Y, Liang X, Zhu Z, Li W *,?and Ou?G.* (2013)??Conditional Targeted Genome Editing Using Somatically Expressed TALENs in C. elegans.?Nature Biotechnology. 2013 Oct;31(10):934-7.

5. ? ?Feng G, Yi P,? Yang Y, Chai Y, Tian D, Zhu Z, Liu J, Zhou F, Cheng Z, Wang X, Li W,?and Ou?G.* (2013) Developmental Stage-Dependent Transcriptional Regulatory Pathways Control Neuroblast Lineage Progression. Development. 2013 Aug 14.

6.????Wang X, Zhou F, Lv S, Yi P, Zhu Z, Yang Y, Feng G, Li W,?and Ou?G.* (2013)?Transmembrane protein MIG-13 links the Wnt signaling and Hox genes to the cell polarity in neuronal migration.?Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):11175-80.?

7. ? ?Chai Y, Tian D, Feng G, Cheng Z, Yang Y, Li W and Ou, G.* (2012)??Apoptotic Regulators Promote Midbody Degradation in C. elegans.?Journal of Cell Biology. 2012 Dec; 199(7):1047-55.

8. ? ?Li W, Zou W, Yang Y, Chai Y, Chen B, Cheng S, Tian D, Wang X*, Vale RD* and Ou, G.* (2012) Autophagy genes function sequentially to promote apoptotic cell corpse degradation in the engulfing cell. Journal of Cell Biology. 197(1):27-35. ?

9. ? ?Ou, G.*, Stuurman N, D'Ambrosio, M and R.D. Vale*. (2010) Polarized myosin produces unequal size daughters during asymmetric cell division. Science. 330(6004):677‐80.

10.??Ou, G., Blacque, O.E., Snow, J.J., Leroux, M.R., and J.M. Scholey (2005) Functional Coordination of Intraflagellar Transport Motors. Nature.? 436(7050):583-7.?

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