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孙前文

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孙前文

研究员,博士生导师,青年千人计划(2015),优秀青年科学基金(2018

电子邮件:sunqianwen(a t)mail.tsinghua.edu.cn

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2014-?????????研究员,清华大学 生命科学学院,清华-北大生命科学联合中心

2009-2014? ??博士后,John Innes Centre

2004-2009 ???博士? 华中农业大学 生科院

2000-2004??? 学士 华中农业大学 生科院

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本实验室研究方向

我们感兴趣基因组调控的各层面,重点关注特殊染色质结构 R-loop的形成、稳定与解除的分子机理以及相应的生物学功能。

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已发表论文:

l 2015年至今,*通讯作者论文:

14.? Yuan W#, Zhou J#, Tong J#, Zhuo W, Wang L, Li Y, Sun Q*, Qian W*, ALBA protein complex reads genic R-loops to maintain genome stability in Arabidopsis. Science Advances, 2019 May 15;5(5): eaav9040.

13.? Zhao S#, Cheng L#, Gao Y#, Zhang B#, Zheng X, Wang L, Li P*, Sun Q*, Li H*. Plant HP1 protein ADCP1 links multivalent H3K9 methylation readout to heterochromatin formation. Cell Res. 2019 Jan;29(1):54-66.

12.? Cheng L, Shafiq S, Xu W, Sun Q*. EARLY FLOWERING IN SHORT DAYS (EFS) regulates the seed size in Arabidopsis. Sci China Life Sci. 2018 Feb;61(2):214-224.

11.? Yang Z#, Hou Q#, Cheng L#, Xu W, Hong Y, Li S, Sun Q*. RNase H1 Cooperates with DNA Gyrases to Restrict R-Loops and Maintain Genome Integrity in Arabidopsis Chloroplasts. The Plant Cell. 2017 Oct;29(10):2478-2497 (#contributed equally).

10.? Xu W, Xu H, Li K, Fan Y, Liu Y, Yang X*, Sun Q*. The R-loop is a common chromatin feature of the Arabidopsis genome. Nature Plants. 2017 Sep;3(9):704-714.

9.? Shafiq S#, Chen C#*, Yang J, Cheng L, Ma F, Widemann E, Sun Q*. DNA Topoisomerase 1 Prevents R-loop Accumulation to Modulate Auxin-Regulated Root Development in Rice. Molecular Plant. 2017 Jun;10(6):821-833 (#contributed equally).

8.? Shafiq S, Li J, Sun Q*. Functions of plants long non-coding RNAs. Biochim Biophys Acta. 2016 Jan;1859(1):155-62.

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l 2014年之前:

7. ?Csorba T#, Questa JI#, Sun Q# and Dean C. Antisense COOLAIR mediates the coordinated switching of chromatin states at FLC during vernalization. Proc Natl Acad Sci USA. 2014. 111:16160-5 (#contributed equally).

6. ?Wang ZW, Wu Z, Raitskin O, Sun Q and Dean C. Antisense-mediated FLC transcriptional repression requires the P-TEFb transcription elongation factor. Proc Natl Acad Sci USA. 2014. 111:7468-73.

5. ?Marquardt S, Raitskin O, Wu Z, Liu F, Sun Q and Dean C. Functional Consequences of Splicing of the Antisense Transcript COOLAIR on FLC Transcription. Mol Cell. 2014. 54:156-65.

4. ?Sun Q, Csorba T, Skourti-Stathaki K, Proudfoot NJ and Dean C. R-Loop Stabilization Represses Antisense Transcription at the Arabidopsis FLC Locus. Science. 2013. 340:619-21.

3. ?Qin FJ, Sun QW, Huang LM, Chen XS and Zhou DX. Rice SUVH histone methyltransferase genes display specific functions in chromatin modification and retrotransposon repression. Mol Plant. 2010. 3:773-82.

2. ?Sun Q and Zhou DX. Rice jmjC domain-containing gene JMJ706 encodes H3K9 demethylase required for floral organ development. Proc Natl Acad Sci USA. 2008. 105:13679-84.

1. ?Huang L#, Sun Q#, Qin F, Li C, Zhao Y and Zhou DX. Down-regulation of a SILENT INFORMATION REGULATOR2-related histone deacetylase gene, OsSRT1, induces DNA fragmentation and cell death in rice. Plant Physiol. 2007. 144:1508-19. (#contributed equally).

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