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李雪明


李雪明

电子邮件lixueming@mail.tsinghua.edu.cn?

主页:? em.life.tsinghua.edu.cn

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本实验室研究方向

主要从事冷冻电子显微学理论和方法研究,着重于开发和利用最新的电子显微学技术,以提高冷冻电子显微学三维重构的分辨率到原子水平;同时致力于将电子显微学应用到结构生物学研究中去,以解决与结构相关的重要生物学问题。

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代表性科研论文:

?● ?Soyeon Park*,?Xueming Li*, Homin Kim*, Chingakham Ranjit Singh, Geng Tian, Martin A. Hoyt, Scott Lovell, Kevin P. Battaile, Michal Zolkiewski, Philip Coffino, Jeroen Roelofs, Yifan Cheng, and Daniel Finley, Reconfiguration of the proteasome during chaperone-mediated assembly,?Nature,?497, 512-516, 2013. (*co-first author)

● ??Xueming Li, Paul Mooney, Shawn Zheng, Chris Booth, Michael B. Braunfeld, Sander Gubbens, David A. Agard and Yifan Cheng, Electron counting and beam-induced motion correction enable near atomic resolution single particle cryoEM,?Nature Methods,?10, 584-590, 2013.

? Featured in Nature Methods News and Views: Robert M. Glaeser (2013) Stroboscopic imaging of macromolecular complexes. Nature Methods?10, 475-476.

? Featured in Nature Methods:?Method of the Year 2013.

?●???Xueming Li, Shawn Zheng, Kiyoshi Egami,David A. Agard, Yifan Cheng, Influence of electron dose rate on electron counting images recorded with the K2 camera,?J Struct. Biol.,?184, 251-260, 2013.

?●???Patricia Grob, Derek Bean, Dieter Typke,?Xueming Li, Eva Nogales, and Robert M. Glaeser, Ranking TEM cameras by their response to electron shot noise,?Ultramicroscopy, 1331-7,?2013

?●???Shenping Wu, Agustin Avila-Sakar, JungMin Kim, David S. Booth, Charles H. Greenberg, Andrea Rossi, Maofu Liao,?Xueming Li, Akram Alian, Sarah L. Griner, Narinobu Juge, Yadong Yu, Claudia M. Mergel, Javier Chaparro-Riggers, Pavel Strop, Robert Tampé, Robert H. Edwards, Robert M. Stroud, Charles S. Craik, Yifan Cheng, Fabs enable single particle cryoEM studies of small proteins,?Structure,?20, 582-592, 2012.

?●???Agustin Avila-Sakar,?Xueming Li, Shawn Q. Zheng, and Yifan. Cheng, Recording high-resolution images of two-dimensional crystals of membrane proteins, Chapter 8, Electron crystallography of soluble and membrane proteins,?Methods in Molecular Biology,?955, 129- 152, 2012.

?●???Xueming Li, Nikolaus Grigorieff, Yifan. Cheng, GPU-enabled FREALIGN: accelerating single particle 3D reconstruction and refinement in Fourier space on graphics processors,?J Struct Biol.,?172, 407-12, 2010

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In Physics and material science

??Xueming Li, Fanghua Li, Huiqian Luo, Lei Fang, Hai-hu Wen, Transmission electron microscopy study of one-dimensional incommensurate structural modulation in superconducting oxides Bi2+xSr2-xCuO6+δ?(0.1≤x≤0.4),?Superconductor Science and Technology,?22, 065003, 2009

??Xueming Li, Fanghua Li, Haifu Fan, A revised version of the program VEC,?Chinese Physics B,?18(6), 2459-2463, 2009

??Binghui Ge, Yumei Wang,?Xueming Li, Fanghua Li , H.L. Song, H.J. Zhang, A study of an incommensurately modulated structure in Ca0.28Ba0.72Nb2O6?by electron microscopy,?Philosophical Magazine Letters,?88, 213 – 217, 2008

??Binghui Ge, Fanghua Li,?Xueming Li, Yumei Wang, Zhenhua Chi, Changqing Jin, Study of superstructure II in multiferroic BiMnO3,?Chinese Physics B,?17, 3163-3169, 2008

??Xueming Li, Si-ze Yang, Xingfang Wu, Preparation of Silicon Carbide Nitride Films on Si Substrate by Pulsed High-Energy Density Plasma,?Journal of University of Science and Technology Beijing,?13(3), 272-276, 200613(3), 272-276, 2006

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