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钟毅

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钟毅

电子邮件:zhongyi@biomed.tsinghua.edu.cn

电话:+86-10-62783873(实验室)

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研究方向:

研究学习记忆和记忆相关神经系统疾病的细胞分子机理。综合运用行为、分子、遗传、免疫组化和电生理和成像学手段,以果蝇作为主要的实验动物,研究记忆和遗忘的机制及神经环路。利用在记忆和遗忘研究中获得的新线索,探索记忆相关神经系统疾病的发病机制,筛选治疗药物并在小鼠上进行验证。

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代表性科研论文:

1. Xie, Z., et al. (2013). "Requirement of the combination of mushroom body gamma lobe and alpha/beta lobes for the retrieval of both aversive and appetitive early memories in Drosophila." Learn Mem 20(9): 474-481.

2. Wang, L., et al. (2012). "Epidermal growth factor receptor is a preferred target for treating Amyloid-beta-induced memory loss." Proc Natl Acad Sci U S A 109(41): 16743-16748.

3. Huang, C., et al. (2012). "A Permissive Role of Mushroom Body alpha/beta Core Neurons in Long-Term Memory Consolidation in Drosophila." Curr Biol.

4. Shuai Y, Hu Y, Qin H, Campbell RA,?Zhong Y*. (2011) Distinct molecular underpinnings of Drosophila?olfactory trace conditioning.?Proc Natl Acad Sci U S A?108: 20201-20206.

5. Shao L, Shuai Y, Wang J, Feng S, Lu B, Li Z, Zhao Y, Wang L,?Zhong Y*.(2011) Schizophrenia susceptibility gene?dysbindin?regulates glutamatergic and dopaminergic functions via distinctive mechanisms in?Drosophila.?Proc Natl Acad Sci U S A?108: 18831-18836.

6. Shuai Y, Lu B, Hu Y, Wang L, Sun K,?Zhong Y*.?(2010) Forgetting is regulated through Rac activity in?Drosophila.?Cell?140:579-89.

7. Chiang HC, Wang L, Xie Z, Yau A,?Zhong Y*. (2010) PI3 kinase signaling is involved in Aβ-induced memory loss in?Drosophila.?Proc Natl Acad Sci U S A?107:7060-7065.

8. Pagani MR, Oishi K, Gelb BD,?Zhong Y*. (2009) The phosphatase SHP2 regulates the spacing effect for long-term memory induction.?Cell?139:186-98.

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