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刘志博

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刘志博

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电子邮件:zbliu@pku.edu.cn

电话:?+86-010-62759191

研究领域:放射化学?PET活体成像

实验室主页:www.chem.pku.edu.cn/zliu

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科研经历:
2016.07-至今,特聘研究员,北京大学化学与分子工程学院
2016.07-至今,中心研究员,北大-清华生命科学联合中心
2014.09–2016.07,博士后研究员,美国国立卫生研究院
2010.09–2014.09,博士,英属哥伦比亚大学化学系
2011.05–2014.09,跨学科博士培养项目,TRIUMF原子能国家实验室
2012.03–2014.09,跨学科博士培养项目,英属哥伦比亚肿瘤中心
2010.06,理学学士,南京大学化学化工学院化学系

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研究方向:
PET影像开辟了在分子层面上进行疾病诊断的新思路,它是精准医疗的排头兵。 近来,PET分子影像已成为了我国各大医院的常规检查项目,市场份额在2015年超过了100亿元。与X射线、CT及MRI等传统临床影像不同, PET影像的诊断效果依赖于放射性标记的分子探针。但是,由于放射化学的特殊性以及多学科融合的复杂性,我国在PET分子探针上的基础研究还相对落后,与国际先进水平差距巨大。即使是国内顶尖的医疗机构,也不得不从国外引进PET探针,辅助国内的临床研究。回国之后,我们计划在北大化院、北大-清华生命联合中心以及周边医学院所的支持下,搭建起我国第一个立足基础研究的PET分子影像平台,填补国内空白,切实推动我国精准医疗事业的发展。

主要的研究方向如下:

1. PET分子影像引导的活体蛋白激活及药物释放;
2. 外源放疗及内源核素衰变激活的活体蛋白激活及药物释放;
3. 含硼PET分子影像探针及硼中子捕获治疗药物的研究与临床应用;
4. 新型医用核素的加速器生产研究与临床应用。

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代表性科研论文:?

1.Dongban Duan, Hui Liu, Mengxin Xu, Mengqi Chen, Yuxiang Han, Yaxin Shi, Zhibo Liu* Size-Controlled Synthesis of Drug Loaded Zeolitic Imidazolate Framework in Aqueous Solution and Size Impact on Their Cancer Theranostics In Vivo. ACS Appl. Mater. Interfaces., 2018, 10 (49), 42165-42174

2.Yaxin Shi, Jiyuan Li, Zizhu Zhang, Dongban Duan, Zhengchu Zhang, Hui Liu, Tong Liu, Zhibo Liu* Tracing Boron with Fluorescence and PET Imaging of Boronated Porphyrin Nanocomplex for Imaging Guided Boron Neutron Capture Therapy. ACS Appl. Mater. Interfaces., 2018, 10 (50), 43387-43395

3.Mengxin Xu, Yuxiang Han, Guizhong Liu, Yang Xu, Dongban Duan, Hui Liu, Felix Du, Peter Luo, Zhibo Liu* Preclinical Study of A Fully Human Anti-PD-L1 Antibody as A Theranostic Agent for Cancer Immunotherapy. Mol Pharm. 2018, 15(10): 4426-4433.

4.Cong Li, Hui Liu, Dongban Duan, Zhenhan Zhou, Zhibo Liu* Preclinical Study of An 18F-Labeled Glutamine Derivative for Cancer Imaging. Nucl Med Biol, 2018, 64, 34-40

5.Dongban Duan, Hui Liu, Yang Xu, Yuxiang Han, Mengxin Xu, Zhengchu Zhang, Zhibo Liu*. Activating TiO2 Nanoparticle: Gallium-68 Serves As A High-Yielded Photon Emitter for Cerenkov Induced Photodynamic Therapy. ACS Appl. Mater. Interfaces. 2018, 10 (6), 5278–5286

6.Hui Liu,?Yuxiang Han,?Jiyuan Li,?Ming Qin,?Qunfeng Fu,?Chunhong Wang,?Zhibo Liu*. A 18F-labeled Alanine Derivative Serve as An ASCT2 Marker for Cancer Imaging. Mol Pharm., 2018, 15 (3), 947-954

7.Zhibo Liu*, Xiaoyuan Chen* Simple Bioconjugate Chemistry Serves Great Clinical Advances: Albumin as A Versatile Platform for Diagnosis and Precision Therapy. Chem. Soc. Rev., 2016, 45, 1432-1456

8.Zhibo Liu*, Haojun Chen, Kai Chen, Yihan Shao, Dale O. Kiesewetter, Gang Niu, Xiaoyuan Chen* Boramino Acid as A Marker for Amino Acid Transporter. Science Advances, 2015;1:e1500694 (co-corresponding author, highlighted on C&EN News)

9.Zhibo Liu*, Kuo-Shyan Lin, Fran?ois Bénard, Dale O. Kiesewetter, David M. Perrin*, Xiaoyuan Chen* A Broadly Applicable One-step 18F-Labeling Protocol with Organotrifluoroborates. Nat. Protoc, 2015, 10, 1423–1432 (co-corresponding author)

10.Zhibo Liu, Maral Pourghiasian, Gemma Dias, Joseph Lau, Francois Benard, Kuo-shyan Lin, David M. Perrin, An Organotrifluoroborate for Broadly Applicable One-Step 18F-Labeling, Angew. Chem. Int. Ed., 2014, 53, 11876–11880 (Cover feature, highlighted on C&EN News)

11.Zhibo Liu, Mark Alex Radtke, May Q. Wong, Kuo-Shyan Lin, Donald Yapp, David M. Perrin, Dual Mode Fluorescent PET Tracers: Efficient modular synthesis of Rhodamine-[cRGD]2-Alkyl-18F-Trifluoroborate, Rapid 18F-labeling at very high specific activity, In vivo PET Imaging, and Ex vivo fluorescence, Bioconjugate Chem. 2014, 25, 1951–1962 (Cover feature)

12.Zhibo Liu, Maral Pourghiasian, Francois Benard, Jinhe Pan, Kuo-Shyan Lin, David M. Perrin, Preclinical Evaluation of A High Affinity 18F-Trifluorborate Octreotide Derivative for Somatostatin Receptor Imaging, J Nucl Med., 2014, 55, 1499-1505 (SNMMI Best Paper Award)

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