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胡家志

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胡家志

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电子邮件:hujz@pku.edu.cn

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研究方向:

免疫系统是保护人类免受疾病困扰的一道重要屏障,其中获得性免疫系统可以特异识别病原并实现定向清除。淋巴细胞及其效应分子──淋巴细胞受体(包括抗体),是免疫系统特异清除病原的关键。为能识别种类众多的病原,淋巴细胞受体在产生之初追求大而全,具有极高的分子多样性;而淋巴细胞受体发挥功能如识别肿瘤细胞等的时候,又追求专而快,展现出极高的结合特异性,从而使之成为比较理想的药物载体。研究淋巴细胞受体从多样性到特异性的成熟过程,是免疫基因组学的重要研究内容。此外研究淋巴细胞与肿瘤的对抗过程及内在机制,有助于我们深入了解免疫系统的作用机理及肿瘤的发生发展过程,以期能定向工程化淋巴细胞受体使免疫系统能更有效地拮抗癌症。
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代表性科研论文

Lin SG#, Ba Z#, Du Z#, Zhang Y, Hu J* & Alt FW*. (2016). A highly sensitive and unbiased approach for elucidating antibody repertoires. Proc Natl Acad Sci USA 113(28):7846-51. doi:10.1073/pnas.1608649113.

Hu J#, Meyers RM#, Dong J, Panchakshari RA, Alt FW* & Frock RL*. (2015). Detecting DNA double-stranded breaks in mammalian genomes by linear amplification-mediated high-throughput genome-wide translocation sequencing. Nature Protocols 11(5): 853-71. doi: 10.1038/nprot.2016.043.
Hu J#, Zhang Y#, Zhao L, Frock RL, Du Z, Meyers RM, Meng F-L, Schatz DG, & Alt FW. (2015). Chromosomal loop domains direct the recombination of antigen receptor genes. Cell 163(4): 947-59. doi: 10.1016/j.cell.2015.10. 016.
Frock RL#, Hu J#, & Alt FW. (2015). Mechanisms of recurrent chromosomal translocations. In book: Chromosomal Translocations and Genome Rearrangements in Cancer. Springer International Publishing, ISBN: 978-3-319-19983-2. doi: 10.1007/978-3-319-19983-2
Frock RL#, Hu J#, Meyers RM, Ho Y-J, Kii E, & Alt FW. (2015). Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases. Nature Biotechnology 33(2):179-86. doi: 10.1038/nbt.3101.
Hu J#, Tepsuporn S#, Meyers RM, Gostissa M*, & Alt FW*. (2014). Developmental propagation of V(D)J recombination-associated DNA breaks and translocations in mature B cells via dicentric chromosomes. Proc Natl Acad Sci USA 111(28): 10269-74. doi: 10.1073/pnas.1410112111.
Tepsuporn S#, Hu J#, Gostissa M*, & Alt FW*. (2014). Mechanisms that can promote peripheral B-cell lymphoma in ATM-deficient mice. Cancer Immunol. Res. 2(9): 857-66. doi: 10.1158/2326-6066. CIR-14-0090.
Hu J, Sun L, Shen F, Chen Y, Hua Y, Liu Y, Zhang M, Hu Y, Wang Q, Xu W, Sun F, Ji J, Murray JM, Carr AM, & Kong D. (2012). The intra-S phase checkpoint pathway targets Dna2 to prevent stalled replication forks from reversing. Cell 149(6): 1221-32. doi: 10.1016/j.cell.2012.04.030.
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其它科研论文(# co-first authors, *co-corresponding authors)
Zhao L#, Frock RL#, Du Z, Hu J, Cheng L, Krangel MS*, Alt FW*. (2016). Orientation-specific RAG activity in chromosomal loop domains contributes to Tcrd V(D)J recombination during T cell development. J Exp Med 213(9): 1921-36. doi: 10.1084/jem.20160670.
Dong J#, Panchakshari RA#, Zhang T#, Zhang Y, Hu J, Volpi SA, Meyers RM, Ho Y-J, Du Z, Robbiani DF, Meng F-L, Gostissa M, Nussenzweig MC, Manis JP*, & Alt FW*. (2015). Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching. Nature 525(7567): 134-9. doi: 10.1038/nature14970.

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Meng F-L#, Du Z#, Federation A#, Hu J, Wang Q, Kieffer-Kwon KR, Meyers RM, Amor C, Wasserman CR, Neuberg D, Casellas R, Nussenzweig MC, Bradner JE*, Liu XS, & Alt FW*. (2014). Convergent transcription at intragenic Super-Enhancers targets AID-initiated genomic instability. Cell 159(7): 1538-48. doi: 10.1016/j.cell. 2014.11.014.
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